在多发性骨髓瘤的治疗选择
Junmei Zhao1, Yushan Cui1, Baijun Fang2
1Department of Hematology, Henan Institute of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No.127 of Dongming Road, Zhengzhou, 450000, China.
多发性骨髓瘤中的外骨髓性疾病 (EMD) 是具有攻击性和耐治疗性的. 本综述总结了目前对EMD的治疗选择,并提供基于证据的指导,以改善患者的治疗结果.
科学领域:
- 血液学
- 癌症学
- 免疫学
背景情况:
- 外骨髓干涉 (EMD) 定义了多发性骨髓瘤 (MM) 的攻击性亚型.
- 骨髓外的骨髓亚克隆是EMD的特征,与高风险遗传学,免疫逃避和对治疗的抵抗有关.
- 尽管MM治疗取得了进展,但EMD显著恶化了患者的预后,甚至在免疫治疗中也显示出有限的生存益处.
研究的目的:
- 对多发性骨髓瘤患者的当前治疗策略进行系统审查和总结.
- 为治疗多发性骨髓瘤的临床医生提供基于证据的指导.
主要方法:
- 对患有EMD的MM的治疗选择进行系统的文献审查.
- 基于已公布的数据对治疗疗效和结果的分析.
主要成果:
- 最近的MM疗法 (蛋白酶抑制剂,免疫调节药物,抗CD38抗体) 对EMD存活率的影响有限.
- 尽管在MM治疗和免疫治疗方面取得了进展,但EMD患者的预后仍然很差.
结论:
- 多发性骨髓瘤的治疗选择需要进一步的研究和优化.
- 基于证据的指导对于改善EMD患者的治疗和治疗结果至关重要.
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