精神分裂症中的血液和神经元外囊线粒体破坏
A Ankeeta1, Ashutosh Tripathi2, Bindu Pillai2
1Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA. ankeeta.lnu@uth.tmc.edu.
概括
精神分裂性谱系障碍 (SSD) 与线粒体功能障碍有关. 血液和神经元中自由细胞线粒体DNA (cf-mtDNA) 的升高可能作为SSD的生物标志物,与大脑乳酸水平相关.
科学领域:
- 神经科学
- 生物化学
- 遗传学
背景情况:
- 线粒体功能障碍与神经精神障碍 (如精神分裂症谱系障碍) 有关.
- 在SSD中评估体内大脑线粒体功能具有挑战性.
- 血液中的无细胞线粒体DNA (cf-mtDNA) 和神经元细胞外囊泡 (nEV) 是拟议的生物标志物.
研究的目的:
- 调查血液中的高cf-mtDNA水平和nEVs作为SSD的潜在生物标志物.
- 通过磁共振光谱 (MRS) 测量cf-mtDNA水平与大脑代谢物之间的关联.
- 检查SSD患者的发育性压力,创伤和cf-mtDNA水平之间的关系.
主要方法:
- 在58名SSD患者和33名健康对照人群中测量了血液cf-mtDNA.
- 在一个小组中评估了nEV mtDNA和大脑代谢物水平 (使用MRS).
- 进行了统计分析,以关联cf-mtDNA,代谢物和压力/创伤史.
主要成果:
- 与对照组相比,SSD患者血液和nEV的cf-mtDNA显著升高.
- 在SSD患者的前带皮层中,较高的cf-mtDNA水平与脑乳酸+水平的增加相关.
- 在SSD患者中,增加的发育性压力和创伤与较高的cf-mtDNA水平有关.
结论:
- 血液和nEV cf-mtDNA显示为评估SSD线粒体功能障碍的可访问生物标志物.
- 这些生物标志物可能有助于阐明精神分裂症中异常的生物能量路径.
- 需要进一步复制和开发以获得临床应用.
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