维生素D缺乏,炎症标志物和膝关节关节炎之间的关联:一个回顾性研究
Khaled Swailem1, Mohammed Sadhan2, Gehad Abdullah Al-Mashramah3
1Orthopedic Surgery, Constant & Head of Orthopedic Surgery Department, Sana'a University, General Coordinator of Arab Board of Orthopedic Surgery, Al-Thawra Modern General Hospital, Sana'a, Yemen.
Journal of orthopaedic surgery and research
|August 23, 2025
概括
在膝关节骨关节炎 (OA) 患者中,维生素D缺乏是常见的,与更严重的疼痛和双边疾病有关,但不是炎症. 补充情况
科学领域:
- 骨科和风湿病学
- 营养科学
- 生物化学
背景情况:
- 膝关节关节炎 (OA) 是一种广泛的退行性关节疾病.
- 影响OA严重性的因素包括生物化学,解剖学和生活方式因素.
- 维生素D缺乏在膝关节OA进展和症状中的具体作用需要进一步阐明.
研究的目的:
- 在被诊断为膝关节OA的患者中确定维生素D缺乏的患病率.
- 研究维生素D水平与关键炎症标志物 (ESR,血小板计数) 之间的关联.
- 探索维生素D缺乏与临床症状,包括疼痛和疾病横向性之间的关系.
主要方法:
- 对986名膝关节骨质炎患者进行了3年半的回顾性分析.
- 评估血清维生素D水平,红细胞沉积率 (ESR) 和血小板计数.
- 统计分析以确定维生素D状态,炎症标志物和临床结果之间的相关性.
主要成果:
- 这项研究包括986名膝关节关节炎患者,主要是女性 (85%),平均年龄为52. 95岁.
- 维生素D缺乏的发生率很高 (70.9%),中度缺乏是最常见的 (36.94%).
- 维生素D缺乏与多关节炎和双侧膝关节骨折有显著的关联,但与炎症标志物 (ESR,血小板计数) 没有关联.
结论:
- 在膝关节OA患者中,维生素D缺乏非常普遍,并且与症状严重程度 (多关节炎) 和疾病程度 (双侧OA) 的增加有关.
- 在该群体中,维生素D水平与常见的炎症标志物之间没有发现显著的联系.
- 需要进一步研究维生素D补充剂的治疗潜力及其在膝关节OA治疗中的潜在机制.
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