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Updated: Sep 10, 2025

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切割损伤后的坐骨神经单细胞转录图

Yiben Ouyang1,2, Mingqian Yu1, Tieyuan Zhang2,3

  • 1School of Medicine, Nankai University, No. 94, Weijin Road, Nankai District, Tianjin, 300071, PR China.

Journal of neuroinflammation
|August 24, 2025
PubMed
概括

周围神经受伤阻碍了恢复. 这项研究使用单细胞测序绘制了坐骨神经损伤后的细胞变化图,揭示了免疫和质细胞的关键作用以及改善神经再生的潜在治疗点.

关键词:
TGF-β信号传输质细胞重编程巨细胞异质性神经再生神经纤维细胞细胞相互作用坐骨神经的切断单细胞RNA-seq

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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