含有α和β-环氧与卡纳格利弗洛辛半水合物复合物:设计和特征
Priyanka Gauniya1, Chitra1, Mukesh Pandey2
1Department of Pharmaceutical Sciences, H.N.B. Garhwal University (A Central University), Srinagar (Garhwal), India.
Current pharmaceutical design
|August 24, 2025
概括
这项研究使用循环德克斯综合物增强了卡纳格里夫洛辛 (CANA) 的溶解性和透性. 这些复合物有望改善CANA等可溶性较差的药物的输送.
科学领域:
- 制药科学
- 提供药物
- 物理化学
背景情况:
- 卡纳格利弗洛辛半酸 (CANA) 是一种具有低溶性和透性的BCS IV类抗糖尿病药物.
- 提高CANA的可溶性和透性对于提高其治疗效果至关重要.
研究的目的:
- 提高CANA的可溶性,溶解性和透性.
- 用α-CD和β-CD制备和描述CANA的纳入复合物.
主要方法:
- 进行了相位溶解性研究,以评估与α-CD和β-CD的CANA溶解性.
- 使用冷干燥方法以各种药物与环氧的比率制备了包含复合物.
- 药物的特征包括药物含量分析,FTIR,XRPD,ADXRD,体外溶解和透研究.
主要成果:
- 用α-CD和β-CD复合显著增加了CANA的水溶性 (超过100倍).
- FTIR证实了药物与辅助剂的相互作用,XRPD/ ADXRD表明了复合物的无形化.
- 药物释放和透性得到增强,特别是在β-环极复合物 (如BCD7和BCD8) 中.
结论:
- 循环氨酸的含有复合有效提高了CANA的溶解性和溶解性.
- 这些发现凸显了循环德克斯复合物作为改善难溶药物的生物制药性能的可行策略.
更多相关视频
10:10Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
10.4K
04:40Dynamic Light Scattering Analysis for the Determination of the Particle Size of Iron-Carbohydrate Complexes
Published on: July 7, 2023
2.6K
相关概念视频
Aldehydes and Ketones with Water: Hydrate Formation
4.5K
An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
4.5K
Characteristics and Nomenclature of Copolymers
2.7K
Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
2.7K
Ion Exchange
1.6K
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
1.6K
Plasticizers
493
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
493
Superplasticizers
468
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
468
Waterproofing and Anti-Bacterial Admixtures in Concrete
329
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
329
