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Updated: Sep 10, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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PROTAC 启用配方:聚合物载体 Eudragit EPO 的影响

Nicole Hofmann1,2, Florian Johann1, Katharina Krollik1

  • 1Global Drug Product Development, Orals Development, the Healthcare Business of Merck KGaA, Frankfurter Straße 250, Darmstadt 64293, Germany.

Molecular pharmaceutics
|August 24, 2025
PubMed
概括

射干燥的蛋白质溶解向模拟体 (PROTACs) 的分散体在体内暴露较差. 配方性能取决于胆汁盐和脂,影响PROTAC的溶解和稳定.

关键词:
欧德拉吉特无形固体分散物胆汁盐生物可用性有助于配方蛋白质溶解的目标是木乃伊

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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