外源性雌激素增强雄性灵长类动物的T细胞激活
Patricia A Hahn1, Joan Escrivà-Font2, Eric S Alexander3
1Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL, USA; The Skaggs Graduate School, The Scripps Research Institute, Jupiter, FL, USA.
Cell reports
|August 24, 2025
概括
在雄性中,雌激素治疗改变了免疫反应,并增加了艾滋病毒向的T细胞. 这突显了性别确认激素治疗期间艾滋病毒易受感染的潜在风险.
科学领域:
- 免疫学
- 内分泌学
- 灵长类模型
背景情况:
- 雌激素会影响女性的免疫力和抗感染能力.
- 在性别确认激素治疗 (GAHT) 期间,雌激素的免疫作用尚不清楚.
- 雄性 rhesus macaques (RMs) 为研究 GAHT 的免疫效应提供了一个相关的模型.
研究的目的:
- 在接受17β-雌激醇 (E2) 治疗的男性RM中描述免疫适应.
- 评估E2对先天性和适应性免疫反应的影响.
- 评估T细胞种群的变化,特别是与HIV-1感染相关的变化.
主要方法:
- 男RM接受了E2或安慰剂治疗7个月.
- 综合免疫分析,包括血细胞计数和化学分析.
- 在mRNA疫苗接种后评估免疫反应.
主要成果:
- E2治疗抑制了丸激素,诱导女性化,并改变了血液样本.
- 天生的免疫反应减弱,而T细胞活化增加.
- 在接种疫苗后,接受E2治疗的RM显示CCR5+ CD4+ T细胞的频率较高.
结论:
- 在雄性灵长类动物中,雌激素治疗引发了显著的免疫变化.
- 增加的CCR5+ CD4+ T细胞可能会增加对HIV-1的敏感性.
- 需要进一步的研究来了解超生理性雌激素对GAHT的HIV风险的影响.
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