皮质输出调节皮质回路的产后成熟
Michael Janeček1, Tara Deemyad2, Yi-Chun Shih1
1Department of Psychiatry, University of Pittsburgh, 450 Technology Dr., Pittsburgh, PA 15219, USA; Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA.
Cell reports
|August 24, 2025
概括
早期的基底腺 (BG) 输出形成前额叶皮层 (PFC) 电路. 这项研究揭示了BG对PFC成熟的影响,影响神经活动和突触平衡.
科学领域:
- 神经科学
- 发展神经科学
- 系统神经科学
背景情况:
- 皮层-BG-甲状腺皮层 (CBGT) 环连接背中前额叶皮层 (dmPFC) 和基底 (BG).
- 这些电路在出生后经历了显著的改进.
- 基底对前额叶皮层发育的影响尚不清楚.
研究的目的:
- 调查基底的早期条形输出是否影响dmPFC活动和连接性的成熟.
- 了解基底在引导前额叶皮层网络建立中的作用.
主要方法:
- 在出生后的早期发育过程中,直接或间接地切除基底腺突起神经元.
- 评估dmPFC神经活动和二三层神经元的突触成熟.
主要成果:
- 早期的纹状输出操纵导致dmPFC神经活动的双向变化.
- 这些变化模仿了成熟电路中的皮质动态的基底调.
- 破坏了dmPFC层2/3神经元的突触成熟,改变了激发抑制平衡.
结论:
- 在早产后发育过程中,状细胞输出对皮质活动的调节起着至关重要的作用.
- 基底在引导前额叶皮层网络的建立中起着以前未知的作用.
- 这突显了基底和前额叶皮层之间的相互发展关系.
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