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血液输血中介的瘤微环境在乳腺癌中的重塑

Qinan Yin¹, Shunshun Zhang², Mouna Ouchari³

¹Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China; Department of Radiation Oncology; Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Acta histochemica

|August 24, 2025

概括

输血有助于乳腺癌患者, 但可能通过免疫抑制和恶化的瘤缺氧损害结果. 个性化策略是减轻风险和提高治疗效率的关键.

科学领域:

癌症学
免疫学
输血医学

背景情况:

输血对于治疗乳腺癌并发症如贫血和失血至关重要.
新兴研究表明,输血可能通过免疫调节和瘤微观环境的改变对癌症的结果产生负面影响.
输血相关免疫调节 (TRIM) 可以抑制抗瘤免疫力,可能有助于侵袭性乳腺癌亚型.

研究的目的:

审查输血在乳腺癌治疗中的双重作用.
分析输血对抗治疗和瘤进展的影响.
讨论风险减轻策略和个性化输血方法.

主要方法:

在乳腺癌中检查血液输血的临床益处和风险.
对瘤微环境,免疫反应和缺氧的输血效应分析.
讨论包括白血病减少,ESA,补充铁和血液保护等策略.

主要成果:

输血可以诱导TRIM,抑制细胞毒性免疫力,并可能促进瘤生长.
输血可能会加剧瘤缺氧,降低治疗效果.
使用TIL,PD-L1和ctDNA等生物标志物的个性化方法至关重要.

结论:

在乳腺癌治疗中, 输血既有好处又有风险.
缓解策略和个性化,生物标志物引导的输血方案是必不可少的.
未来的研究应该专注于优化输血时间和免疫调节干预措施.

关键词:

血液输血乳腺癌个性化输血策略与输血相关的免疫调节瘤微环境

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