对双相情感障碍患者,其他精神疾病患者和健康对照患者的认知储备进行比较:系统性审查和多层次元分析
Giulia D'Alessandro1, Constanza Sommerhoff2, Marta Bort2
1Psychiatric Unit 2, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Psychiatry research
|August 24, 2025
概括
与健康对照人群相比,双相情感障碍患者的认知储备较低,这表明其在认知衰退中的作用. 在BD和严重抑郁症 (MDD) 之间没有发现显著差异.
科学领域:
- 神经科学
- 精神病学
- 认知心理学
背景情况:
- 认知储备 (CR) 是缓解精神疾病认知衰退和功能障碍的关键因素.
- 了解双相情感障碍 (BD),其他精神疾病和健康个体之间的CR差异至关重要,但仍不清楚.
研究的目的:
- 系统地审查和元分析患有BD的个体,健康对照 (HCs),风险人群和患有其他精神疾病的患者之间的CR差异.
主要方法:
- 在主要数据库 (PubMed/MEDLINE,Scopus,PsycINFO,Web of Science) 进行了系统的文献搜索,遵循PRISMA指南.
- 在BD和对照组中使用了验证的CR测量或代理值来评估CR.
- 一个多层随机效应的元分析比较了BD和HC之间的CR水平,以及BD和其他精神疾病.
主要成果:
- 包括12项与1861名参与者的研究.
- 患有BD的人的CR显著低于HC人 (SMD=0. 45).
- 在BD和严重抑郁症 (MDD) 之间没有发现显著的CR差异 (SMD=0. 23).
结论:
- 在BD中较低的CR表明有助于认知和功能障碍.
- 在BD和MDD中类似的CR水平表明了共同的临床脆弱性.
- 需要在BD患者中加强CR的干预措施,以及对可修改因素的标准化评估和研究.
相关概念视频
Bipolar Disorder
142
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
142
Mania and Antimanic Drugs: Overview
319
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
319
Depression: Overview
332
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
332


