在老年人体内动态消化过程中增强蛋白质分解和脂质分解动力学
Yang Liu1, Shotaro Yamaguchi2, Yuki Ishigaki2
1Science Center for Future Foods, Jiangnan University, Wuxi 214122, China; School of Biotechnology, Jiangnan University, Wuxi 214122, China.
Food chemistry
|August 24, 2025
概括
用蛋白酶-DS (P-DS) 和脂酶-AP12 (L-AP) 补充奶酪可以显著改善老年人的消化. 这种双酶方法增强了营养释放和胃空气,优化了老年人群的复杂食物消化.
科学领域:
- 营养科学
- 胃肠病学
- 食品科学
背景情况:
- 人口老龄化会导致生理衰退,导致消化诸如奶酪之类的营养丰富食物.
- 奶酪的复杂蛋白质脂质基因难以分解,影响老年人的营养吸收.
研究的目的:
- 在模拟的老年条件下评估蛋白酶-DS (P-DS) 和脂酶-AP12 (L-AP) 对奶酪消化动力学的协同作用.
- 评估双酶补充剂对蛋白质和脂质消化以及胃空化的影响.
主要方法:
- 使用活跃的体外胃肠道模型模拟老年人的生理状况.
- 研究了P-DS和L-AP对奶酪蛋白解和脂解的单独和联合作用.
- 分析了蛋白质的消化性,必需氨基酸的释放性,脂质的生物可获得性和自由脂肪酸的释放动力学.
主要成果:
- 与单个酶和成年模型相比,P-DS和L-AP的组合协同加速了奶酪基质的降解和改善了胃空气.
- 双酶补充剂可使蛋白质的消化率从41. 89%提高到59. 51%,并且可使脂质的生物可获得性从32. 34%提高到70. 24%.
- 动态建模证实了营养释放的增强,P-DS有助于脂质的可访问性,L-AP有助于蛋白酶的作用.
结论:
- 与P-DS和L-AP的协同补充是一种有效的策略,以优化奶酪对老龄化人口的营养.
- 这种酶组合有效地克服了与年龄相关的消化挑战,改善了复杂食物基质中的蛋白质和脂质的生物可访问性.
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