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Updated: May 3, 2026

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
06:07

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

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发现基乙烯衍生物YPD-29B:一种针对编程细胞死亡-1/编程细胞死亡-1 (PD-1/PD-L1) 相互作用的新型临床前化合物

Yang Yang1, Meiqin Xu2, Ke Wang2

  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; College of Medicine, Linyi University, Linyi 276000, China.

Bioorganic & medicinal chemistry
|August 24, 2025
PubMed
概括

研究人员开发了针对PD-1/PD-L1途径的新型小分子抑制剂. 一种化合物YPD-29B表现出强烈的活性,其盐在体内表现出显著的抗黑色素瘤作用,毒性最小.

关键词:
癌症免疫疗法免疫检查点PD-1/PD-L1 其他小分子抑制剂

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