针对瘤微环境中的乳酸代谢:免疫调节和抗瘤治疗的前景
Jingnan Yan1, Yafeng Qi1, Yeyuan Liu1
1Clinical School of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.
International immunopharmacology
|August 24, 2025
概括
在瘤微环境 (TME) 中的乳酸代谢通过抑制免疫反应推动癌症的进展. 针对乳酸提供了增强抗瘤免疫力和改善癌症治疗的新策略.
科学领域:
- 癌症学
- 免疫学
- 代谢研究
背景情况:
- 瘤微环境中的乳酸代谢受损是恶性瘤进展的关键驱动因素.
- 乳酸作为代谢副产品和影响瘤和免疫细胞的信号分子.
- 乳酸重塑TME通过抑制效应免疫细胞和促进免疫抑制细胞来抑制抗瘤免疫力.
研究的目的:
- 系统地审查TME中乳酸代谢的调节网络.
- 分析乳酸在调节各种免疫细胞功能的特定作用.
- 探索针对乳酸代谢进行癌症治疗的新疗法.
主要方法:
- 对TME中乳酸代谢的现有文献进行系统审查.
- 对乳酸对不同免疫细胞群的影响分析.
- 探索治疗途径,包括针对乳酸生产/运输,pH中和基于TCM的干预措施.
主要成果:
- 通过代谢信号与免疫相互作用,乳酸活性重塑TME.
- 乳酸抑制了效应性免疫细胞的活性,并促进了免疫抑制细胞的扩张.
- 这些作用共同削弱了整体抗瘤免疫反应.
结论:
- 了解乳酸在TME中的作用对于开发有效的癌症疗法至关重要.
- 针对乳酸代谢,包括通过TCM,为精确的抗瘤治疗提供了有希望的策略.
- 代谢重塑和组合疗法有可能提高临床癌症治疗的疗效.
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