在多发性硬化症患者使用行走辅助器时探索皮质激活模式
Costanza Iester1, Monica Biggio2, Laura Bonzano3
1Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy.
Multiple sclerosis and related disorders
|August 24, 2025
概括
在使用行走辅助器的多发性硬化症患者中,功能近红外光谱 (fNIRS) 显示出广泛的皮质激活. 曲线行走比线性行走更多地影响了前额头和前运动区域.
科学领域:
- 神经科学
- 康复医学
- 生物医学工程
背景情况:
- 多发性硬化 (MS) 是一种慢性中枢神经系统疾病,导致炎症,脱髓化和轴突损失.
- 运动障碍,特别是行走能力,是影响MS患者生活质量的关键症状.
- 随着MS的进展,行走困难往往需要行走辅助器,影响日常活动.
研究的目的:
- 通过功能近红外光谱 (fNIRS) 在PwMS中使用行走辅助器进行皮质激活模式的调查.
- 为了比较线性与曲线性行走中的神经激活,反映现实世界的移动需求.
- 确定与中度残疾PwMS相关的特定大脑区域.
主要方法:
- 有19名PwMS在扩展残疾状况表 (EDSS) 上得分为6.
- 在30秒行走试验中使用功能近红外光谱 (fNIRS) 来测量皮质活动.
- 参与者沿着线性和曲线性路径行走,
主要成果:
- 无论是线性还是曲线性步行,都引起了PwMS的广泛皮质激活,包括前额,感觉运动和顶部区域.
- 与线性行走相比,在特定的布罗德曼区域 (BA10,BA8,BA6) 中,曲线行走的激活率明显高.
- 在曲线行走过程中前额和前运动区域的激活增加表明认知和运动控制需求更大.
结论:
- 在PwMS中使用辅助工具时皮质激活模式是广泛的,涉及多个大脑区域.
- 具有挑战性的步行机动,如曲线行走,需要加强前额外和前运动皮质区域的招募.
- 对于PwMS的步行康复计划应整合线性和曲线性步行练习,以更好地为患者准备现实世界的移动性.
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