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在患有间歇性肺病 (ILD) 的患者中通过电神经镜评估的隔膜功能障碍,风险因素和对死亡率的影响:一项回顾性观察研究

Jules Milesi1, Sophie Ng Wing Tin2, Thomas Gille2

  • 1Service de Pneumologie, Assistance Publique Hôpitaux de Paris, Hôpital Universitaire d'Avicenne, Bobigny, France; Université Paris 13, Sorbonne Paris Cité, Bobigny, France.

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隔膜功能障碍 (DD) 影响三分之一的间歇性肺部疾病 (ILD) 患者,特别是与结缔组织疾病相关的ILD患者. 这种情况与ILD患者的生存结果较差有关.

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科学领域:

  • 肺病学
  • 神经学
  • 医疗诊断

背景情况:

  • 隔膜功能障碍 (DD) 显著影响呼吸系统疾病患者的生活质量和预后.
  • 在间歇性肺病 (ILDs) 中DD的特征是有限的.
  • 隔膜电神经图 (dENMG) 和复合肌动力潜力 (CMAP) 分析为DD评估提供了潜力.

研究的目的:

  • 使用dENMG和CMAP分析对ILD患者的可能DD进行鉴定.
  • 在ILD患者中确定DD的预测因素.
  • 确定DD对ILD患者存活率的预后影响.

主要方法:

  • 对接受dENMG的ILD患者进行回顾性单中心研究 (2018年5月至2023年9月).
  • 收集的临床数据,dENMG结果和其他评估.
  • 对于DD预测者的逻辑回归;对于生存分析的卡普兰-梅尔和考克斯模型.

主要成果:

  • 评估了37名ILD患者;35%的患者被诊断为DD.
  • 与结合组织疾病相关的ILD (CTD-ILD) 是最常见的亚型.
  • 患者年龄较大,冠状动脉疾病 (CAD) 患病率较高,存活率较低.

结论:

  • DD影响了一组ILD患者,主要是CTD-ILD患者.
  • 在三分之一的疑似病例中,dENMG和CMAP证实了DD.
  • DD与ILD的不良结果有关,需要进一步调查.