通过静电沉增强的腹膜内气溶药物输送的建模和实体评估
Mohammad Rahimi-Gorji1, Yiwen Long2, Amrit Sareen3
1Laboratory of Experimental Surgery (SURGX), Department of Human Structure and Repair, Ghent University, Ghent, 9000, Belgium; IBITECH-BioMMedA, Department of Electronics and information systems, Ghent University, Ghent, 9000, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, 9000, Belgium.
概括
静电沉增强了腹膜内转移的空气中药物递送 (IPADD). 这种改进的方法可确保药物分布更加均,并能更深入地穿透组织,为具有挑战性的癌症提供有前途的治疗方法.
科学领域:
- 生物医学工程
- 癌症学
- 药物输送系统
背景情况:
- 由于化学疗法耐药性,腹膜转移 (PM) 是一个重大挑战.
- 目前的腹膜内溶液药物输送方法 (IPADD) 存在分布不均和组织透不足的问题.
研究的目的:
- 使用静电沉 (eIPADD) 增强IPADD,以改善药物传递到腹膜表面.
- 通过计算模拟和实验验证来评估eIPADD的疗效.
主要方法:
- 使用人腹腔3D模型进行计算流体动力学模拟.
- 在体外和体外实验以评估气溶滴的分布和组织透.
- 电极配置和电位的系统变化.
主要成果:
- 与传统的IPADD相比,eIPADD显著改善了气溶的均性和组织透性.
- 将电极从1个增加到3个进一步提高了分布均性和透深度.
- 最佳电能被确定为10kV左右,超出该值后的效益会停滞.
结论:
- eIPADD提供了一种在腹腔中均输送药物的优质方法.
- 这项技术有潜力克服当前IPADD的局限性,改善腹膜转移的治疗.
- 优化eIPADD参数对于最大限度地提高PM治疗效果至关重要.
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