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Updated: Sep 10, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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高分辨率空间转录学揭示了人类皮肤衰老中的空间分辨率基因模块和脂肪酸代谢失调

Yin Li1, Wenwan Zhang1, Yao Teng2

  • 1Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences.

The Journal of investigative dermatology
|August 24, 2025
PubMed
概括

人体皮肤老化涉及细胞变化,脂肪酸合成减少,导致衰老和屏障功能障碍. 这项研究揭示了皮肤衰老的新分子机制.

关键词:
人类皮肤皮肤老化空间转录学立体声段

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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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