在接受常见外科手术的患者中,术前阻塞性睡眠呼吸暂停诊断与术后长期使用阿片类药物之间的联系
Anjali A Dixit1, Akash Shanmugam2, Christine Y Kim3,4
1Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California, USA anjalid@stanford.edu.
Regional anesthesia and pain medicine
|August 24, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与手术后长时间使用阿片类药物无关. 这项研究没有发现任何关联,这表明OSA可能不是长期术后阿片类药物使用的可修改风险因素.
科学领域:
- 医学研究
- 临床结果
- 卫生信息学
背景情况:
- 确定可修改的患者风险因素对于减少长期术后阿片类药物使用至关重要.
- 阻塞性睡眠呼吸暂停 (OSA) 已被提议为潜在的危险因素,但其与长期使用阿片类药物的关联尚不清楚.
研究的目的:
- 研究术前阻塞性睡眠呼吸暂停 (OSA) 诊断与术后长期使用阿片类药物之间的关联.
- 确定OSA是否是一个可改变的风险因素,影响手术后长期使用阿片类药物.
主要方法:
- 使用MarketScan商业和医疗保险索赔数据库 (2016-2021) 的行政医疗保险索赔数据.
- 接受过11项常见手术的未使用过阿片类药物的患者.
- 通过多变量逻辑回归分析,术前OSA根据ICD-10代码和术后长期使用阿片类药物为≥10处方或≥120天的供应.
主要成果:
- 包括270,320名患者;10. 8%的患者在手术前被诊断为OSA.
- 在多变量调整后,在OSA和非OSA组中,长期使用阿片类药物的发生率为0. 4% (p=0. 184).
- 在各种分析规格中,结果一致.
结论:
- 在手术前诊断OSA并没有增加长期使用阿片类药物的风险.
- 研究结果表明,OSA可能不是一般外科患者长期使用阿片类药物的可修改风险因素.
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