心血管 - 代谢综合征0 - 3阶段的人群中C反应蛋白 - 三甘油糖指数与未来心血管疾病风险之间的关联
Zhihui Lu1, Long Li1, Xiaolin Wang2
1Department of Cardiology, The Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, China.
Scientific reports
|August 24, 2025
概括
在心血管--代谢综合征 (CKM) 的早期阶段,C-反应蛋白- 三甘油- 葡萄糖 (CTI) 指数与心血管疾病 (CVD) 的风险增加有关. 较高的CTI水平表明风险更高,这表明其用于风险分层.
科学领域:
- 心脏病学
- 代谢综合征
- 生物标志物
背景情况:
- 心血管 - - 代谢综合症 (CKM) 突显了代谢,和心血管疾病之间的联系.
- C反应蛋白- 三甘油- 葡萄糖 (CTI) 指数是胰岛素耐药性和炎症的一个建议生物标志物.
研究的目的:
- 调查CKM综合征0-3阶段患者中CTI指数与心血管疾病 (CVD) 风险之间的关联.
- 确定CTI是否可以作为这一群体中心脏病风险分层的实际工具.
主要方法:
- 使用中国健康和退休长度研究 (CHARLS) 的数据进行的前性队列研究,随访期为10年.
- 暴露:CTI是从甘油三,禁食血糖和C反应蛋白计算的.
- 分析:可克斯比例危险回归和限制立方线 (RCS) 分析.
主要成果:
- 较高的CTI与患心血管疾病的风险显著相关.
- 每增加1个单位的CTI与心血管疾病风险增加16%相关 (HR=1.16,95% CI:1. 06-1. 27).
- 与最低组相比,最高CTI组的CVD风险增加了42% (HR=1. 42,95% CI: 1. 20-1. 68).
- RCS分析显示CTI和心血管疾病风险之间存在非线性关联 (总体P< 0. 001,非线性P=0. 01).
结论:
- 在早期CKM综合征患者中,CTI指数与心血管疾病风险有积极的关联.
- 在此群体中,CTI可能是评估心脏病风险的有价值和实用的工具.
- 进一步的研究可以探索CTI在治疗CKM综合征和预防心血管事件中的作用.
更多相关视频
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
371
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
7.7K
相关概念视频
01:30Coronary Artery Disease I: Introduction
55
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
55
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
213
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
213
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
119
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
119
01:28Chronic Kidney Disease III: Interprofessional Care
78
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
78
01:26Atherosclerosis III: Management
33
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
33
01:26Coronary Artery Disease IV: Preventive Measures
32
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
32