用于按需释放药物的多多巴胺涂层双乳液囊,减少被动泄漏
Hyojun Lee1, Giyeong Nam1, Daehoon Han2
1School of Chemical Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.
Scientific reports
|August 24, 2025
概括
聚多巴胺 (PDA) 涂层增强了双乳液囊 (DEC) 的稳定性,减少了药物的被动泄漏. 有PDA涂层的DEC通过光热激活提供按需的药物释放,改进了可控的输送系统.
科学领域:
- 生物材料科学
- 药物输送系统
- 聚合物化学
背景情况:
- 双乳液 (DE) 封装了水友性和疏水性药物,但缺乏可控释放的稳定性.
- 双乳液囊 (DEC) 提供了更好的稳定性,但药物通过多孔外扩散.
- 聚多巴胺 (PDA) 是一种具有强粘性,适用于生物医学涂料的生物相容,稳定的聚合物.
研究的目的:
- 对双乳液囊 (DEC) 的聚多巴胺 (PDA) 涂层进行研究,以提高稳定性和控制药物释放.
- 评估PDA涂层对DEC被动药物泄漏的影响.
- 通过光热激活来证明PDA涂层DEC的按需释放药物.
主要方法:
- 双乳液囊 (DEC) 的制造
- 在优化条件下用多多巴胺 (PDA) 覆盖DEC.
- 随着时间的推移对被动药物泄漏的评估.
- 由近红外 (NIR) 激光照射触发的按需药物释放的演示.
主要成果:
- 与未涂层的DEC相比,PDA涂层在8天内可显著减少DEC的被动药物泄漏量约20%.
- 为了有效地覆盖表面和增强稳定性,建立了最佳的PDA涂层条件.
- 在NIR激光照射后通过PDA层的光热加热成功实现了按需释放药物.
结论:
- 有PDA涂层的DEC是稳定和可控药物输送的有希望的平台.
- 通过PDA的光热特性,可以调节药物释放,从而提高治疗潜力.
- 这种方法为向药物输送,植入疗法和精准医学应用提供了进步.
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