在帕金森病下下丘脑神经刺激后,言语变化的临床预测因素
Francesco Cavallieri1, Francesco Bove2, Alessandro Zampogna3,4
1Neurology Unit, Neuromotor & Rehabilitation Department, Azienda USL- IRCCS di Reggio Emilia, Reggio Emilia, Italy.
概括
在帕金森病 (PD) 患者中,手术前的语言障碍和较大的运动增长预测了脑下核深度刺激 (STN-DBS) 后的短期语言恶化. 长期的语言变化与手术前的波动有关.
科学领域:
- 神经学
- 神经外科
- 语言科学
背景情况:
- 帕金森病 (PD) 显著影响言语.
- 脑下核深度刺激 (STN-DBS) 是高级PD的治疗选择.
- 在STN-DBS后的术后语言变化可能在患者之间有很大差异.
研究的目的:
- 在双边STN-DBS患者中预测言语变化的术前临床因素.
- 分析短期 (1年) 和长期 (10年) 的语言结果.
主要方法:
- 对接受双边STN- DBS的324名PD患者的人口,临床和神经成像数据的回顾性分析.
- 使用UPDRS/MDS-UPDRS语音分值对术前非药物状态进行语音变化的评估.
- 单变量和多变量逻辑回归分析以确定预测因素.
主要成果:
- 总体而言,42. 6%的人没有言语变化,34. 9%的人改善,22. 5%的人在STN- DBS后的一年后恶化.
- 在手术前停用药物后的语音评分和运动改善程度预测了1年的语音变化.
- 在长期的小组中,手术前的每日波动时间与言语恶化相关.
结论:
- 在STN-DBS之后,PD的语音结果是异质的.
- 术前语言障碍和显著的运动改善是短期语言恶化的关键预测因素.
- 在手术前的波动模式可能会影响长期的语音轨迹.
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