原衍生含有的循环二可防止UVB照射的表皮角质细胞中与光衰老相关的炎症反应
Yuki Kumazawa1, Kazunori Mizuno1, Yuki Taga1
1Nippi Research Institute of Biomatrix, Toride, Ibaraki, Japan.
Photochemistry and photobiology
|August 25, 2025
概括
通过减少活性氧物种 (ROS) 和炎症,Cyclo (X-Hyp) 和H-GDCH有效地对抗皮肤光衰老. 这些化合物在护肤和功能性食品中的抗衰老成分具有前景.
科学领域:
- 皮肤学和化品
- 生物化学和分子生物学
背景情况:
- 反应性氧物种 (ROS) 是UV辐射诱导的皮肤光衰的关键驱动因素.
- 此前开发了一种新型的原化物 (H-GDCH),富含氧 (Hyp) 的循环二 (cyclo(X-Hyp)).
研究的目的:
- 研究Cyclo (X-Hyp) 和H-GDCH对人类皮肤细胞中UVB诱导的炎症的抗光衰老作用.
- 评估环氧化物清除能力和抗炎机制.
主要方法:
- 正常的人类表皮角质细胞 (NHEK) 被UVB照射.
- 评估了细胞内ROS水平,炎症途径 (NF-κB,MAPK),MMP- 2/ MMP- 9表达和IV型原水平.
- 使用人体皮肤扩展剂评估了cyclo(X-Hyp) 的皮肤透程度.
主要成果:
- 与线性双和含有Pro的循环双相比,Cyclo (X-Hyp) 显示出更高的ROS清除活性.
- 抑制了NF-κB和MAPK通路的UVB诱导激活,减少了MMP- 2/ MMP- 9并保留了IV型原.
- H-GDCH还抑制了UVB诱导的ROS产生和下游的炎症反应.
- 在人体皮肤中有效透.
结论:
- 通过减轻ROS和炎症,Cyclo (X-Hyp) 和H-GDCH具有显著的抗衰老潜力.
- 这些化合物可用于用于皮肤健康的化品和功能性食品.
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