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基线营养状况,心理健康,疲劳和失眠对高级非小细胞肺癌免疫检查点抑制剂的结果的影响:回顾性队列研究
Yu-Xuan Zhu1, Yuan-Yuan Zhang1, Xiu-Juan Jiang2
1Geriatric Oncology Department, Nanjing Drum Tower Hospital, Nanjing, China.
The Kaohsiung journal of medical sciences
|August 25, 2025
概括
治疗前的营养,心理健康,疲劳和失眠等因素对晚期非小细胞肺癌 (NSCLC) 免疫检查点抑制剂 (ICI) 治疗结果产生重大影响. 解决这些问题可能会改善患者的生存率和治疗反应.
科学领域:
- 癌症学
- 免疫疗法
- 癌症护理
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 的治疗依赖于免疫检查点抑制剂 (ICI).
- 患有ICI的患者结果可能受到各种基线因素的影响.
- 在治疗前全面评估患者的状况至关重要.
研究的目的:
- 研究治疗前营养状况,心理健康,疲劳和失眠对高级NSCLCICI单一治疗结果的影响.
- 确定可能受益于针对性干预的患者子组.
- 与治疗反应,无进展生存期 (PFS) 和整体生存期 (OS) 相关联.
主要方法:
- 评估了80名接受ICI单独治疗的IV期NSCLC患者.
- 基线评估包括控制营养状况 (CONUT) 评分,赫斯希望指数 (HHI),医院焦虑和抑郁量表 (HADS),简要疲劳量表 (BFI) 和雅典失眠量表 (AIS).
- 在治疗后评估了治疗反应,PFS和OS.
主要成果:
- 渐进性疾病 (PD) 与更高的CONUT分数,更大的焦虑和抑郁,以及更严重的疲劳和失眠有关.
- 营养风险较低,希望更高,焦虑,抑郁,疲劳和失眠的分数较低与生存率更高有关.
- 焦虑独立预测PFS, 而抑郁和疲劳预测OS.
结论:
- 治疗前的营养状况,心理健康,疲劳和失眠显著影响了晚期NSCLC的免疫治疗反应和存活率.
- 综合性基线评估对于识别高风险患者至关重要.
- 针对这些因素的早期干预可以提高治疗效果和患者的存活率.
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