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研究领域生物科学生物化学和细胞生物学细胞相互作用 (包括粘附,基质,细胞壁)
使用BET建模和SERS光谱对病毒吸附和共吸附行为的定量分析

使用BET建模和SERS光谱对病毒吸附和共吸附行为的定量分析

Jiaheng Cui ¹, Yanjun Yang ², Amit Kumar ², Jackelyn Murray ³, Les Jones ³, Xianyan Chen ⁴, Ralph A Tripp ³, Yiping Zhao ²

Jiaheng Cui ¹, Yanjun Yang ², Amit Kumar ²

¹School of Electrical and Computer Engineering, College of Engineering, The University of Georgia, Athens, Georgia 30602, United States.
²Department of Physics and Astronomy, The University of Georgia, Athens, Georgia 30602, United States.
³Department of Infectious Diseases, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30605, United States.
⁴Department of Epidemiology & Biostatistics, College of Public Health, The University of Georgia, Athens, Georgia 30602, United States.

⁰School of Electrical and Computer Engineering, College of Engineering, The University of Georgia, Athens, Georgia 30602, United States.

The Journal of Physical Chemistry. A +

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2025年八月25日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

病毒混合物比单个病毒更强烈地吸附到表面,影响生物传感器的准确性. 了解这些复杂的病毒表面相互作用是开发可靠诊断工具的关键.

科学领域

纳米技术
生物物理
分析化学

背景情况

病毒与表面的相互作用对于生物传感器的开发和抗病毒策略至关重要.
精确检测呼吸道病毒需要了解它们在传感器表面的吸附行为.
现有的模型往往忽视了病毒混合和生理环境的复杂性.

研究的目的

在SiO2涂层的银纳米基阵列上系统地研究12种呼吸道病毒的吸附和共吸附.
通过修改的布鲁纳uer-Emmett-Teller (BET) 框架和表面增强的拉曼散射 (SERS) 来建模病毒吸附.
分析水和人唾液中的病毒行为,考虑单个病毒 (SV) 和二进制病毒混合物 (2VM).

主要方法

在SiO2涂层的银纳米基数组上使用SERS进行病毒分析.
应用修改的BET吸附框架来建模光谱数据.
使用线性最小正方形光谱分解来提取吸附系数.

主要成果

所有12种呼吸道病毒都表现出多层物理吸收 (II型异热体).
二元病毒混合物 (2VMs) 显示显著增强吸附 (比SVs大25倍的BET常数q).
人类唾液以病毒特异的方式调节病毒表面相互作用,增加复杂性.

结论

单个病毒的校准不足以准确检测混合病毒样本.
混合感知分析模型对于推进生物感知应用至关重要.
这项研究为诊断和监测环境中的病毒吸附提供了定量建模的框架.

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相关概念视频

Analyte Adsorption and Distribution

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In certain chromatographic separations, solutes transfer between the mobile phase and the stationary phase via sorption, which typically refers to the process of adsorption. For many chromatographic systems, the sorption process often depends on the polarity of the compounds—an expression of the overall dipole moment within the molecule. During the separation process, there is competition between the solute and solvent for adsorption to the stationary phase. Highly polar compounds and...

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