年轻成年人的动脉硬和经组织学确认的Helicobacter pylori感染
Hack-Lyoung Kim1, Dong-Hoon Kim2, Kyueng-Whan Min3
1Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
Helicobacter
|August 25, 2025
概括
杆菌 (HP) 感染与年轻成年人的动脉硬度增加有关. 较高的HP严重程度与较大的动脉硬相关,这表明早期检测可能会降低心血管风险.
科学领域:
- 心血管健康
- 胃肠病学
- 血管生物学
背景情况:
- 杆菌 (HP) 感染与全身炎症和血管功能障碍有关.
- 关于HP感染对年轻人早期心血管影响的研究有限.
- 动脉硬是心血管风险的早期指标.
研究的目的:
- 在年轻成年人中调查组织学确认的HP感染与动脉硬之间的关联.
- 确定HP感染的严重程度是否与动脉硬程度相关.
- 为了探索HP感染与动脉硬的独立关联,调整混因素.
主要方法:
- 对7803名参与者的健康检查数据进行了回顾性分析.
- 通过胃活检确认HP感染的19至39岁的年轻人.
- 使用估计的脉冲波速度 (ePWV) 和更新的悉尼系统 (USS) 评分来评估动脉硬度.
主要成果:
- 在53. 9%的参与者 (4289人) 中存在HP感染.
- 与HP阴性个体相比,HP阳性个体的EPWV显著更高 (6. 66±0. 60对6. 33±0. 58米/秒;p < 0. 001).
- 在USS得分和ePWV之间发现了正相关性 (p < 0. 001),严重的HP感染与ePWV升高的可能性增加了3. 87倍.
结论:
- 在年轻成年人中,HP感染与动脉硬度增加有关.
- 根据USS评分,HP感染的严重程度与较高的ePWV水平相关.
- 早期检测和治疗HP感染对于减轻年轻人的长期心血管风险至关重要.
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