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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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人体表皮生长因子受体2 [HER-2/neu] 放大和微卫星稳定状态在胃和胃食道腺癌:在伊朗癌症研究所评估频率和预后影响

Samaneh Salarvand1, Abbas Mohammadi2, Reza Shahsiah1

  • 1Department of Clinical and Anatomical Pathology, Cancer Institute, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

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概括

在患有胃癌的伊朗患者中,人体表皮生长因子受体-2 (HER-2) 表达不常见,并与较低的存活率有关,而微小卫星不稳定性高 (MSI- H) 是罕见的,但显著改善了结果. 需要进一步的研究来指导个性化治疗.

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腺癌 癌症DNA不匹配的修复胃新生体她的家庭受体

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科学领域:

  • 癌症学
  • 分子生物学
  • 遗传学

背景情况:

  • 分子向疗法和免疫疗法对胃腺癌的治疗具有前景.
  • 人体表皮生长因子受体-2 (HER-2) 放大和微卫星不稳定性 (MSI) 状态预测对这些疗法的反应.
  • 评估HER-2和MSI频率对于胃癌的个性化治疗策略至关重要.

研究的目的:

  • 确定MSI状态和HER-2表达的频率在伊朗胃和胃食道腺癌患者的预治疗队列中.
  • 评估HER-2和MSI状态对患者结果的预后意义.

主要方法:

  • 对135例胃腺癌的档案组织进行了HER-2/ neu表达和不匹配修复 (MMR) 系统分析.
  • 对66个样本进行了MSI分析.
  • 分析了与HER-2和MSI状态相关的总生存率 (OS) 和无疾病生存率 (DFS).

主要成果:

  • 在8. 1%的患者中发现了HER-2放大,在HER-2阳性患者中出现了较短的OS和DFS的趋势 (分别为p=0. 18和p=0. 25).
  • 在66名患者中,有3名患者出现微观卫星不稳定性高 (MSI- H) (4.5%).
  • 在随访期间,MSI- H患者的生存状况和DFS显著改善 (p=0. 018和p=0. 020),没有复发,转移或死亡.

结论:

  • 在伊朗的胃腺癌患者中,HER-2表达较少,并显示出不显著的不良结果趋势.
  • 在这一群体中,MSI-H状态是罕见的,这表明许多人受益于免疫疗法,但少数人可能仍然受益.
  • MSI-H与改善的生存率和减少的周围神经侵袭有关,因此需要对其预后价值和个性化治疗中的作用进行进一步的临床研究.