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肠道微生物群在调节环境因素引起的氧化应激中的作用

Natalia Kurhaluk¹, Piotr Kamiński^2,3, Halina Tkaczenko¹

¹Institute of Biology, Pomeranian University in Słupsk, Arciszewski St. 22 B, 76-200 Słupsk, Poland.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

|August 25, 2025

概括

环境污染物破坏肠道微生物群,导致氧化应激和炎症. 这篇评论探讨了抗击这些健康风险的益生菌和便移植等针对微生物的机制和治疗方法.

科学领域:

环境科学
微生物学
毒理学

背景情况:

环境污染物 (金属,微塑料,抗生素) 改变肠道微生物群,诱导失生症和氧化应激.
这种失调有助于全身炎症,线粒体功能障碍和肠道屏障完整性的损害.
了解这些分子机制对于公共卫生和疾病预防至关重要.

研究的目的:

综合分析环境污染物,肠道失调和氧化应激之间的分子机制.
审查针对微生物群的治疗干预措施,以减轻污染物引起的氧化损伤.
综合最近关于人类和动物健康问题的研究.

主要方法:

在2016年至2024年间发表的354项研究的系统审查和综合.
包括NF-κB,Nrf2/Keap1,PI3K/AKT,p38-MAPK,JAK/STAT和TLR4/MyD88在内的分子通路的分析.
评估治疗策略,如益生菌,益生菌,多,后生菌和便微生物移植.

主要成果:

环境污染物通过氧化还原失衡和反应性氧物种过度产生氧化损伤.
通过短链脂肪酸的产生和抗氧化活性的破坏,肠道失调会加剧氧化压力.
治疗干预措施在调节关键信号通路 (Nrf2,AMPK) 和恢复肠道健康方面具有潜力.

结论:

环境污染物通过氧化应激对肠道微生物群和宿主健康构成重大威胁.
准肠道微生物群为抵消污染物造成的损害提供了有希望的治疗途径.
为了制定有效的应对广泛环境暴露的策略, 需要进一步的研究.

关键词:

肠道屏障完整性; 免疫调节; 炎症通路; 污染; 肠道微生物群和污染物调节; 微生物群与宿主相互作用; 氧化应激通路

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