预生菌与胆组合的实体研究,以调节肠道细菌,提高胆的生物可用性,减少TMA的产生
Ying Qi Goh1,2, Guoxiang Cheam3,2, Mingyue Yeong1
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.
Microbiome research reports
|August 25, 2025
概括
补充胆和银酸糖 (GOS) 可以调节肠道微生物以提高胆的生物可用性并减少三甲基胺 (TMA) 的产生,从而可能改善心血管健康.
科学领域:
- 微生物组研究
- 营养生物化学
- 代谢健康
背景情况:
- 胆对细胞功能至关重要,但其生物可用性因肠道微生物转化为三甲基胺 (TMA) 而降低,这是一种与心血管疾病相关的TMA N-氧化物 (TMAO) 的前体.
- 诸如银寡糖类 (GOS) 这样的前生物可以调节肠道微生物群的组成和功能.
研究的目的:
- 研究结合胆和益生菌对肠道微生物组成和代谢物产生的影响,特别关注胆的生物可用性和TMA生成.
- 鉴定受胆和GOS补充影响的特定微生物种类和代谢途径.
主要方法:
- 使用人体便微观系统,补充胆和各种益生菌.
- 目标代谢学量化胆和TMA水平.
- 分析了肠道微生物组成的变化.
主要成果:
- 补充了Galactooligosaccharides (GOS) 显著降低了胆转化为TMA.
- 这种降低与蓝菌等有益细菌的增加和Clostridia的减少有关,其中包括Clostridium citroniae,它含有负责TMA生成的cutC基因.
- 微生物转移影响了关键的代谢途径,包括胆酸盐生物合成和酸盐和甲酸盐的途径.
结论:
- 胆和GOS的联合补充是一种调节肠道微生物群的新策略.
- 这种方法可以提高胆的生物可用性,减少TMA的产生,为改善代谢和心血管健康提供潜在途径.
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