在患有青光眼,眼睛高血压或类固醇反应的患者中,超胆固醇氨酸的眼内压力结果
Nicholas R Bello1, Robert C Wang2, Joseph Boss3,4
1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Journal of vitreoretinal diseases
|August 25, 2025
概括
与其他类固醇相比,高危患者的眼内压力 (IOP) 升高的趋势较低. 大多数先前有类固醇反应的患者在治疗后没有显著的内血压增加.
科学领域:
- 眼科 眼科
- 药理学
背景情况:
- 眼内类固醇治疗是常见的,但可以提高眼内压力 (IOP).
- 患有青光眼,眼睛高血压或先前有类固醇反应的患者患内血压升高的风险较高.
- 超冠状腺注射是一种较新的眼内类固醇输送途径.
研究的目的:
- 在高风险患者中评估超胆固醇氨酸对内脏压力的作用.
- 为了比较有史以来青光眼,眼高血压或类固醇反应的患者的内血压反应率.
主要方法:
- 多中心,回顾性队列研究.
- 接受超胆固醇氨酸的患者的检查表 (2022年2月至2023年12月).
- 在基线和随访时记录了内压.
主要成果:
- 在59个眼睛中,有17%的眼睛内血压增加了≥5mm Hg.
- 5% 的眼睛的最终内血压> 25 mm Hg;没有超过35 mm Hg.
- 79% 具有先前类固醇反应的眼睛没有显示≥5 mm Hg的内血压增加.
结论:
- 与已公布的数据相比,超胆固醇氨酸在高危眼睛中显示出较低的内血压升高趋势.
- 对于容易受到类固醇诱导的内血压升高的患者来说,这种途径可能更安全.
- 对所有接受局部皮质类固醇治疗的患者进行密切的内压监测是必不可少的.
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