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在异性造血干细胞移植后的病毒性肠炎:病原体,临床特征和结果

Hai-Lu Sun¹, Xiang-Yu Zhao¹, Xiao-Dong Mo¹

¹Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.

Frontiers in medicine

|August 25, 2025

概括

病毒性肠炎是异构造血干细胞移植 (allo-HSCT) 后的常见并发症. 细胞巨病毒 (CMV),HHV-6和EBV是常见的原因,CMV与生存率较低有关.

科学领域:

胃肠病学
传染性疾病
血液学

背景情况:

病毒性肠炎常常会使异构造血干细胞移植复杂化 (异构造血干细胞移植).
有限的数据存在于常见的肠道病毒,临床特征和HSCT后的结果.
了解这些因素对于患者的管理至关重要.

研究的目的:

描述病毒性肠炎的流行病学,临床表现和结果.
确定最常见的病毒病原体导致移植后肠炎.
评估特定病毒感染,特别是CMV对患者生存的影响.

主要方法:

在alo-HSCT后通过肠道活检诊断出59名病毒性肠炎患者的回顾性分析.
使用活检样本识别病毒病原体.
收集临床数据,包括症状,持续时间,并发移植对宿主疾病 (GVHD) 和存活率.

主要成果:

人类疹病毒6 (HHV-6) 和爱斯坦- 巴尔病毒 (EBV) 是最常见的病原体 (37. 3%, 37. 3%, 33. 9%).
主要症状是腹和腹痛,35名患者的腹持续时间长 (中位数为16天).
与其他病毒类型相比,CMV肠炎的总生存率显著降低 (P=0. 035).

结论:

病毒性肠炎是一种显著的HSCT后并发症,通常由CMV,HHV-6和EBV引起.
早期诊断和及时治疗至关重要.
CMV肠炎带来更高的不良结果和减少生存的风险.

关键词:

爱斯坦-巴尔病毒整体造血干细胞移植细胞巨核病毒人类疹病毒6 病毒性肠炎

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