在代谢功能障碍相关的肥胖性肝病中,使用血清肌素和囊素C查指数的比较
Inyoung Hwang1, Shi-Ra Lee1,2, Yun Kim3
1Department of Clinical Pharmacology and Therapeutics, Hanyang University Seoul Hospital, Seoul, Republic of Korea.
Frontiers in medicine
|August 25, 2025
概括
在与代谢功能失调相关的脂肪性肝病 (MASLD) 患者中,计算体肌量 (CBMM) 有效地查了肉症. 这种可访问的方法有助于早期发现和干预低骨肌指数 (SMI).
科学领域:
- 肝病学
- 老年病学
- 代谢疾病
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 和肉症经常同时存在,共享共同的病理生理路径.
- 在MASLD患者中诊断肉症是困难的,因为症状重叠,需要专门的设备.
- 在MASLD中,可访问的查方法对于早期检测皮症至关重要.
研究的目的:
- 在MASLD患者的低骨肌指数 (SMI) 查中,比较血清指数的有效性,包括计算的体质肌量 (CBMM),肉症指数 (SI) 和估计的淋巴细胞过率 (eGFR).
- 在MASLD的背景下,评估这些血清衍生指数作为潜在的肉类的生物标志物.
主要方法:
- 一项涉及146名MASLD参与者的前性观察研究.
- 使用血清肌和囊C水平计算CBMM,SI和eGFR比率.
- 使用生物电阻分析 (BIA) 评估低SMI,并通过ROC曲线分析和机器学习模型 (线性回归,随机森林,XGBoost) 评估血清指数的辨别能力.
主要成果:
- 较高的FIB-4分数与较低SMI的流行率相关.
- 与SI和eGFR相比,CBMM与SMI的相关性最强 (R2=0. 4306) 和优异的辨别能力 (AUC:男性0. 9149,女性0. 9444).
- 机器学习模型始终认为CBMM是SMI最重要的预测因素.
结论:
- 从现有的血清标记得出的计算身体肌肉质量 (CBMM) 是查MASLD患者的宝贵工具.
- 这种可访问的查方法可以帮助识别低SMI风险的个体,促进及时干预.
- 在MASLD群体中,CBMM提供了一种有前途,具有成本效益的方法来早期检测肉症.
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