轻度认知障碍中的十字词训练和神经可塑性 (COGIT-2):78周的多地点随机对照试验,认知,功能,成像和生物标志物结局
Laura A Wang1, Terry E Goldberg2,3, Philip D Harvey4
1Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA.
International journal of clinical trials
|August 25, 2025
概括
拼字游戏作为治疗轻度认知障碍 (MCI) 的有希望的策略, 优于计算机训练, 可能减少大脑缩. 进一步的研究将证实它们的有效性和预防阿尔茨海默病的最佳剂量.
科学领域:
- 神经学
- 认知科学
- 神经成像
背景情况:
- 轻度认知障碍 (MCI) 是一个重要的治疗点.
- 认知培训是MCI的一个潜在干预措施.
- 之前的试验表明拼字可能比计算机认知训练更有效.
研究的目的:
- 将高剂量与低剂量十字题训练与MCI患者的健康教育对照效果进行比较.
- 评估十字词训练对认知功能和日常工作的影响.
- 研究十字题训练对阿尔茨海默病相关的脑结构和生物标志物的影响.
主要方法:
- 一项为期78周的多中心随机临床试验 (COGIT-2),涉及240名患有MCI的参与者.
- 家庭高剂量 (每周4个拼图) 和低剂量 (每周1个拼图) 拼图的比较.
- 使用阿尔茨海默病评估尺度-认知子尺度14 (ADAS-Cog14) 的评估,提供者报告的日常功能,MRI和血生物标志物.
主要成果:
- 在之前的试验中, 拼字比计算机认知训练优越, 与大脑缩相关.
- 主要结果是ADAS- Cog14分数的变化.
- 二次结局包括每日功能,海马体积,皮质厚度和特定的血生物标志物 (神经丝光和pTau217) 的变化.
结论:
- 对于患有阿尔茨海默病风险的个体来说, 交叉词训练可能是一个低成本,可扩展的家庭认知增强工具.
- COGIT-2试验将提供有关MCI十字词干预的有效性和最佳频率的关键数据.
- 确认有效性可能会导致广泛采用作为预防认知衰退的策略.
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