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ALDOB是一种预后生物标志物,也是清细胞癌的潜在免疫治疗标

Wu Xu¹, Dali Wu¹, Cuilian Li¹

¹Department of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guanzhou, China.

|August 25, 2025

概括

在清细胞癌 (ccRCC) 中降低的阿尔多B (ALDOB) 水平与预后不佳和免疫细胞透增加相关. 这表明ALDOB可以作为ccRCC进展的预测生物标志物.

科学领域:

癌症学
生物化学
免疫学

背景情况:

阿尔多B (ALDOB) 在癌症中具有复杂的,有争议的作用,既起瘤抑制作用,又起瘤促进作用.
它与清细胞癌 (ccRCC) 的预后和免疫细胞的具体关系尚不清楚.

研究的目的:

研究ALDOB在ccRCC中的预后意义.
探索ALDOB表达,临床病理特征和瘤免疫微环境之间的关联.

主要方法:

使用多个数据库的生物信息分析 (TCGA,GEO,HPA,UALCAN,TIMER).
在组织微阵列上进行免疫组织化学 (IHC) 验证ALDOB表达.
与临床参数和瘤透免疫细胞 (TIIC) 相关的ALDOB水平.

主要成果:

与病态T,N和M阶段,组织学等级和性别相关的ALDOB表达.
较低的ALDOB水平与不良的疾病特异性存活率,无进展间隔和整体存活率 (p < 0. 001) 有关.
降低ALDOB与ccRCC中Treg,Th17细胞和中性粒细胞的透增加有关;IHC证实ccRCC组织中的ALDOB降低.

结论:

减少ALDOB表达是ccRCC预后不佳的重要指标.
ALDOB水平与临床特征和免疫透模式相关.
ALDOB可以作为ccRCC进展和患者结局的潜在预测生物标志物.

关键词:

美国清细胞细胞癌一个GEO 在HPA 免疫组织化学预测情况美国时间表瘤免疫微环境乌尔坎地区

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