在mRNA COVID-19和流感疫苗接种后出现的耳科不良事件的比较:匹配的队列分析
Tina Munjal1,2, Shelley Batts1, Saurabh Gombar3,4
1Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Frontiers in neurology
|August 25, 2025
概括
COVID-19 疫苗接种和流感疫苗接种对耳部病的不良反应具有相似的安全性. 在mRNA COVID-19疫苗和流感疫苗接种后,新发性听力损失,耳和头是罕见的.
科学领域:
- 耳鼻喉科
- 疫苗学
- 流行病学
背景情况:
- 在接种COVID-19疫苗后,偶尔会有耳部病变的报道.
- 与之前存在的疫苗相比,这些副作用的发生率尚未得到充分确立.
- 这项研究旨在比较COVID-19和流感疫苗接种之间的耳鼻性副作用.
研究的目的:
- 将接受mRNA COVID-19疫苗接种的成年人与流感疫苗接种的新发性耳部病变 (AE) 的发生率进行比较.
- 评估COVID-19疫苗相对于流感疫苗的耳部安全性.
- 调查特定的副作用,包括听力损失,耳,头和耳痛.
主要方法:
- 使用来自斯坦福医疗保健的电子健康记录 (EHR) 的回顾性队列研究.
- 包括50至89岁的未患有耳部疾病的成年人.
- 在6个月的随访期内,使用高维度倾向分数 (hdPS) 匹配来比较COVID-19疫苗 (COVIDVax) 和流感疫苗 (FluVax) 队列.
主要成果:
- 在hdPS匹配后,每个队列共分析了20325名患者.
- 在FluVax和COVIDVax组中,大多数耳鼻性副作用的发生率同样低.
- 与FluVax患者相比,COVIDVax患者出现头的几率较低,但听力充满的几率较高,尽管听力充满仍然很少 (<0.22%).
结论:
- 在mRNA COVID-19和流感疫苗接种后,新发的耳鼻性异常很少见.
- 这项研究表明这两种疫苗的耳部安全性是相似的.
- 建议在更大的数据库中进行进一步的研究以证实这些发现.
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