探索乳腺癌和结肠癌转移的基于第二和代的预后指标的种族差异
Tresa M Elias1, Danielle E Desa2, Edward B Brown1
1University of Rochester, Department of Biomedical Engineering, Rochester, New York, United States.
Biophotonics discovery
|August 25, 2025
概括
根据患者的种族,第二和生成 (SHG) 分析显示了原结构的差异. 这表明需要特定种族的算法来改善癌症转移的预测.
科学领域:
- 生物医学光学
- 癌症生物学
- 翻译研究
背景情况:
- 目前的转移预测方法在不同种族中缺乏准确性.
- 对原的第二和生成 (SHG) 分析提供了增强预后见解的潜力.
- 光学工具需要通过多中心试验进行临床整合的验证.
研究的目的:
- 调查基于SHG的预后信号是否因患者的种族而异.
- 为设计未来基于SHG的转移预测多中心临床试验提供数据.
- 评估种族对瘤微环境中的原组织的影响.
主要方法:
- 对结肠腺癌 (CRC) 和侵入性导管癌 (IDC) 患者的样本进行了SHG成像.
- 导出了两个预后指标:前向向后的SHG散射比 (F/B) 和纤维角度变化率 (FAV).
- 在黑人和白人患者中比较了F/ B和FAV.
主要成果:
- 在IDC队列中,瘤-肌瘤界面的F/B比率显示出人口群体之间的显著差异.
- 在CRC队列的瘤-肌瘤界面和瘤体积中观察到F/B差异的趋势.
- 纤维角度可变性 (FAV) 在任何一个队列中都没有显著的差异.
结论:
- 根据种族观察到的F/B变化表明预后关系可能取决于种族.
- 这些发现强调了种族特异性预测算法的潜在必要性.
- 根据患者的种族定制算法可以提高所有个体的转移预测准确度.
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