自体免疫性疾病患者的subdoligranulum基因的变化:系统性审查和元分析
Lu Shen1, Ying Zhao1, Shuting Liu2
1Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Frontiers in immunology
|August 25, 2025
概括
在患有器官特异性自身免疫性疾病的患者中发现肠道细菌Subdoligranulum的水平较低. 这些发现表明Subdoligranulum与自身免疫性疾病的发展之间存在联系.
科学领域:
- 肠道微生物组研究
- 免疫学
- 微生物致病
背景情况:
- 自免疫性疾病与肠道微生物组的改变和肠道屏障功能障碍是共同的.
- 一种肠道细菌被认为是局部肠道炎症的原因.
- 了解Subdoligranulum的作用对于自身免疫疾病研究至关重要.
研究的目的:
- 系统地审查Subdoligranulum与自身免疫性疾病之间的关系.
- 在各种自身免疫疾病中评估Subdoligranulum丰度的变化.
- 探讨子粒体与炎症标志物之间的关联.
主要方法:
- 在PubMed,Cochrane,Web of Science和Embase的系统文献搜索.
- 在患者和健康对照组中比较Subdoligranulum水平的元分析.
- 分析不同治疗过程中的亚细粒体变化以及与生物标志物的相关性.
主要成果:
- 包括12项与1,792名参与者的研究.
- 与对照组相比,大多数自身免疫性疾病患者观察到较低的子粒度 (p=0. 027).
- 与CRP,LBP和Treg细胞具有正相关性,与IL-8具有负相关性.
结论:
- 在器官特异性自身免疫性疾病中,subdoligranulum的丰度下降.
- 在全身性自身免疫疾病中没有发现Subdoligranulum的一致变化.
- 亚细粒体变化可能导致自身免疫性疾病的发病.
相关概念视频
01:29Autoimmune Disorders
671
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
671
01:17Chronic Bowel Disorders: Introduction
540
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
540
01:30Inflammatory Bowel Disease II: Crohn's Disease
382
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
382