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早期口服补充剂在患有后内镜逆行性胆管瘤学胰腺炎的患者:随机对照试验
Jung Hyun Jo1, Jae Min Lee2, Dong Kee Jang3
1Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Gut and liver
|August 25, 2025
概括
在轻度后内镜逆行性胆道瘤学胰腺炎 (PEP) 中,早期口服补充 (ERF) 显著减少了住院时间. 这种方法是安全有效的,没有增加严重并发症或死亡的风险.
科学领域:
- 胃肠病学
- 临床医学
- 医学研究
背景情况:
- 后内镜逆行性胆血管瘤学胰腺炎 (PEP) 是一个常见的并发症.
- 评估最佳养策略对于患者的康复和资源管理至关重要.
研究的目的:
- 在轻度PEP患者中比较早期口服补充剂 (ERF) 与延迟补充剂 (DRF) 的安全性和有效性.
主要方法:
- 这是一项随机对照试验,涉及80名轻度PEP患者.
- 患者被分配到ERF (诊断后24小时开始食) 或DRF (在肠道声音恢复和疼痛减轻后开始食).
- 主要结局是住院时间;次要结局包括严重PEP发病率,再入院和死亡率.
主要成果:
- 与DRF相比,ERF显著减少了PEP住院时间 (2.93天与3. 78天,p=0. 026).
- 在这两组中,少数患者 (4 ERF,3 DRF) 出现了再食中断.
- 在ERF和DRF组中,严重急性胰腺炎,再入院和死亡率相似.
结论:
- 早期口服补充是缩短轻度PEP患者住院时间的有效策略.
- 在这种患者群体中,ERF不会增加严重并发症,再入院或死亡的风险.
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