在晚期癌症患者中个性化突破性疼痛目标和反应
Sebastiano Mercadante1, Alesssandra Casuccio2, Guglielmo Noce1
1Main Regional of Supportive/Palliative Care, La Maddalena Cancer Center, Palermo, Italy.
European journal of pain (London, England)
|August 25, 2025
概括
在缓解性护理中的晚期癌症患者报告说,经过突破性疼痛 (BTP) 药物治疗后,整体印象有所改善. 患者疼痛目标 (PPG) 和患者疼痛目标反应 (PPGR) 是个性化疼痛管理的关键.
科学领域:
- 缓和护理
- 癌症学
- 治疗疼痛
背景情况:
- 突破性疼痛 (BTP) 是急性息治疗单元 (APCU) 中晚期癌症患者面临的一个重大挑战.
- 评估以患者为中心的结果,如患者的整体印象 (PGI) 和患者的疼痛目标 (PPG),对于有效的疼痛管理至关重要.
研究的目的:
- 在接受BTP药物治疗的晚期癌症患者中评估PGI,PPG和患者疼痛目标反应 (PPGR).
- 了解BTP强度,PGI,PPG和PPGR之间的关系.
主要方法:
- 使用长度研究设计对230名进入APCU的晚期癌症患者进行研究.
- 在服用BTP药物之前和之后的不同时间点测量BTP强度,PGI,PPG和PPGR.
主要成果:
- 在药物治疗后,BTP强度从T0的6. 5显著降低到T30的2. 3.
- 90. 8% 的患者报告PGI有所改善,46. 1% 在T30时达到PPGR.
- 较高的初始BTP强度和较低的治疗后BTP强度与PGI独立相关.
结论:
- PPG是个性化患者护理和随着时间推移评估疼痛反应的重要工具.
- PPG,PGI和PPGR是支持疼痛评估和临床决策的关键以患者为中心的指标.
- 虽然患者的疼痛目标可能很难实现,但BTP药物治疗后患者对疼痛缓解的总体印象是积极的,无论使用哪种阿片类药物.
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