立即装载和卸载的小螺丝中的细胞因子水平:分口随机临床试验
Mariah Carboni Mendes1, Gabriela Leite Pedroso1, Paôla Caroline da Silva Mira1
1Department of Orthodontics, School of Dentistry of Ribeirão Preto, University of São Paulo (USP) - Ribeirão Preto, São Paulo, Brazil.
Journal of orthodontics
|August 25, 2025
概括
立即加载的正牙迷你螺丝显示较高的炎症生物标志物水平,但没有损失,表明骨对即时加载的反应正常. 这表明直接加载的机械应力是可以很好地容忍的.
科学领域:
- 牙整形
- 牙周病学
- 生物材料
背景情况:
- 牙的微型螺丝对于固定非常重要.
- 越来越多地使用微型螺丝的即时加载.
- 了解生物对即时负荷的反应至关重要.
研究的目的:
- 在卸载和立即加载的迷你螺丝之间比较周围迷你螺丝裂液 (PMCF) 中的炎症生物标志物水平.
- 评估立即加载正牙迷你螺丝的临床结果和骨反应.
主要方法:
- 一个单中心,配对分口受控试验进行.
- 在16名患者中放置了40个小螺丝,随机分配给卸载或立即加载的组.
- 在多个时间点收集周围小螺丝裂液 (PMCF),并使用多重微球免疫检测分析了互白素 (IL) 水平.
主要成果:
- 没有迷你螺丝在任何一组中丢失.
- 在这两组中,生物标志物水平随着时间的推移显著增加.
- 与未加载的微型螺丝相比,立即加载的微型螺丝显示出显著更高的生物标志物水平,除了7天后的IL-10.
结论:
- 尽管炎症标志物升高,但立即加载正牙迷你螺丝并没有导致故障.
- 这表明骨对机械压力的反应是平衡和适应性的.
- 立即加载似乎不会对临床结果产生负面影响.
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