通过通过p38 MAPK调节细胞内ROS来控制血淋巴中的Vibrio水平
Jiawei Cheng1, Yunyu Shi1, Yonghui Kong1
1Guangdong Provincial Key Laboratory of Marine Biotechnology, Institute of Marine Sciences, Shantou University, Shantou, China.
Virulence
|August 25, 2025
概括
海的血清素对细胞健康至关重要,调节抗氧化基因和反应性氧物种 (ROS),以维持免疫功能和控制细菌水平.
科学领域:
- 海洋无脊椎动物免疫学
- 细胞氧化还原稳定
- 主体与微生物的相互作用
背景情况:
- 反氧反应对细胞健康和宿主微生物相互作用至关重要,特别是在海洋无脊椎动物中.
- 血清素在这些生物体内的氧化还原调节中的作用尚不清楚.
- 维持氧化还原平衡对于免疫防御和微生物平衡至关重要.
研究的目的:
- 研究血素在血细胞中调节氧化还原的作用.
- 研究血对抗氧化剂和亲氧化剂基因表达和活性氧物种 (ROS) 水平的影响.
- 确定血清素对免疫功能和血淋巴病毒的影响.
主要方法:
- 在中降低血清素.
- 对抗氧化剂 (POD,GPX) 和亲氧化剂 (XOX) 基因表达的分析.
- 在血细胞和氧化还原酶活动中测量ROS水平.
- 对p38-MAPK-c-Jun信号通路的研究.
- 血淋巴病毒种类的量化 丰富的时间.
主要成果:
- 降低血清素破坏了关键的氧化还原相关基因的表达,并改变了酶活动.
- 在血清细胞中观察到高ROS水平.
- 通过p38-MAPK-c-Jun信号通路,发现血清素可以控制血细胞的氧化还原平衡.
- 由血清素受影响的ROS水平Vibrio spp 丰富的时间.
结论:
- 血清素作为一种重要的抗氧化剂,调节血细胞中的氧化还原平衡.
- 血清素在的免疫防御和微生物平衡中起着重要作用.
- 这些发现为海洋无脊椎动物的抗氧化机制提供了新的见解.
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.7K
01:37The Unfolded Protein Response
5.1K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
5.1K
01:28Gene Regulation in Microbial Communities: Quorum Sensing
92
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
92
01:20Extrinsic and Intrinsic Pathways of Hemostasis
9.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
9.2K