比克特格拉维尔与多卢格拉维尔单片剂治疗方案的实际持续性:加拿大大型城市艾滋病毒诊所的回顾性队列研究
在PubMed上查看摘要
概括
此摘要是机器生成的。与含有杜洛特格拉维尔 (DTG) 的治疗方案相比,单片双重/ 丁胺 (BIC/ FTC/ TAF) 的治疗方案显示患者持久性较高,不良反应较少.
科学领域
- 传染性疾病
- 药理学
- 艾滋病毒/艾滋病研究
背景情况
- 使用像比克特格拉维尔 (BIC) 和杜洛格拉维尔 (DTG) 这样的整合酶抑制剂的单片剂疗法是HIV治疗的标准.
- 这些方案提供了有效性和方便性,但对长期持续性的直接比较至关重要.
研究的目的
- 为了比较含有BIC/ emtricitabine (FTC) / tenofovir alafenamide (TAF) 和dolutegravir (DTG) 的STR之间停药的时间.
- 在现实临床环境中确定停止治疗的原因和相关的风险因素.
主要方法
- 从2016年至2022年开始使用BIC/FTC/TAF或DTG-STR的1732名艾滋病毒成年人的回顾性队列分析.
- 用卡普兰-梅尔曲线和考克斯比例危险模型来分析停药的时间.
- 停止治疗的原因被分类,包括不良事件,患者偏好,成本和病毒学失败.
主要成果
- 总体而言,22. 3% 的参与者停止了STR治疗,平均持续时间为402天.
- 与含有DTG的STR (29. 9%) 相比,BIC/ FTC/ TAF的终止率显著较低.
- 与含有DTG的STR (12. 5%) 相比,BIC/ FTC/ TAF的不良反应是停止治疗的主要原因.
结论
- 与含有DTG的STR相比,BIC/FTC/TAFSTR具有更高的持久性和更好的安全性.
- 这些发现支持个性化艾滋病毒治疗策略,优化患者的长期结果.
- 这项研究强调了在治疗艾滋病毒和尽量减少治疗中断时考虑STR类型的重要性.
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