在CIDP中,Jamar手握动力仪的最小临床重要差异:韩国-英国研究
Young Gi Min1, Zeinab Rajabally2, Woohee Ju3
1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
European journal of neurology
|August 25, 2025
概括
在慢性炎症性脱髓性多基隆性神经病 (CIDP) 中提出了新的握力 (GS) 门. 该研究建议改善5公斤,恶化4.5公斤,比目前的10%相对变化准则更准确.
科学领域:
- 神经学
- 临床测量
- 生物统计学
背景情况:
- 抓握强度 (GS) 是慢性炎症性脱髓性多基隆神经病 (CIDP) 评估中的一个关键指标.
- 目前的指导方针建议10%的相对变化作为临床重要差异 (MCID),通常需要平均每日测量.
- 检测恶化和非每日监测的最佳门仍未确定.
研究的目的:
- 确定CIDP患者握力变化的精确MCID值.
- 评估拟议的绝对和相对GS变化值的准确性.
- 为CIDP管理提供可靠的监测指南.
主要方法:
- 分析了来自两个国际中心的122名CIDP患者的350个GS评估.
- 使用患者感知和验证尺度 (INCA,ONLS,IRSD) 的临床变化 (改善,恶化,稳定) 的分类.
- 应用Youden指数来确定绝对 (kg) 和相对 (%) 变化的最佳MCID值.
主要成果:
- 该指南建议的10%的相对值显示其特异性和准确性较低.
- 获得的改善值为5kg,恶化值为4.5kg显示出更高的特异性和准确性.
- 20%的相对变化值也被证明是检测任何方向变化的有效率.
结论:
- 目前在CIDP中GS的10%的相对MCID不足以进行可靠的单日评估.
- 建议的值 (5kg改善,4. 5kg恶化,20%相对) 提供了增强的诊断特异性.
- 这些精确的值可以提高CIDP患者的常规监测可靠性.
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