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Updated: Sep 10, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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基于哺乳期生理学上的药物动力学模型的应用,以预测被动扩散药物的牛奶暴露

Ruhul Kayesh1, Michelle Pressly1, Daphne Guinn1

  • 1Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Journal of clinical pharmacology
|August 25, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 模型准确地预测了非输送基质在人乳中的药物度. 这些模型显示了通过哺乳期评估婴儿药物暴露的潜力.

关键词:
其他:阿尔普拉佐兰其他药物埃斯基塔洛普拉姆哺乳期模型

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