患有败血症患者心声表现型的发病率和死亡率的时间过程:系统性审查和元分析
Jie Wang1, Zewen Tong, Xiaoting Wang
1All authors: Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Critical care medicine
|August 25, 2025
概括
由败血症引起的心肌功能障碍,包括左心室缩/腹功能障碍和右心室功能障碍,遵循一个抛物线模式. 这些情况显著增加了败血症死亡风险.
科学领域:
- 心脏病学
- 危急护理医学
- 传染性疾病
背景情况:
- 败血症可能导致心肌功能障碍.
- 心声检查对于诊断心脏功能障碍至关重要.
研究的目的:
- 调查心肌功能障碍的回声心脏表征的时间进展.
- 评估这些功能障碍对败血症相关死亡率的影响.
主要方法:
- 涉及17008名败血症患者的65项研究的系统综述和元分析.
- 包括通过心声学诊断的新发性心肌功能障碍的研究.
- 分析左心室静缩功能障碍 (LVSD),左心室静缩功能障碍 (LVDD) 和右心室静缩功能障碍 (RVD).
主要成果:
- 心肌功能障碍发生在48小时内达到峰值,并在72小时内下降.
- 发生率最高:LVSD 33%,LVDD 46%,RVD 47%.
- LVSD,LVDD和RVD与显著更高的死亡风险相关 (RR分别为1.57,1.36和1.62).
结论:
- 血引起的心肌功能障碍表现出一个抛物线时间模式.
- 心脏功能障碍的回声心脏学表型是败血症死亡率的重要预测因素.
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