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Updated: May 11, 2026

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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在产前暴露于EDC混合物NeuroMix后,HPG轴上的转录组变化

Tyler M Milewski1, Madeline Streifer1, Lindsay M Thompson1

  • 1Division of Pharmacology & Toxicology; The University of Texas at Austin, Austin, TX, 78712, USA.

Endocrinology
|August 25, 2025
PubMed
概括

产前暴露于内分泌干扰化学物质 (EDC) 会改变大鼠生殖组织中的基因表达. 在暴露于EDC混合物NeuroMix后,该研究揭示了下丘脑-垂体-淋巴结核 (HPG) 轴的性别特异性分子变化.

关键词:
干扰内分泌的化学物质 (EDC)发生性生殖大脑下垂体下垂体转录组学

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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...