与相关的职业暴露和宫癌,卵巢癌和子宫内膜癌的风险:系统审查和元分析
Veer Shah1, Darshi Shah2, Vincent DeStefano2
1Icahn School of Medicine at Mount Sinai, New York, New York, United States.
概括
职业暴露可能会增加女性生殖器癌症的风险,特别是在死亡率数据中. 由于研究的局限性,需要进一步的研究来证实这一关联.
科学领域:
- 环境健康
- 职业医疗
- 妇科瘤学
背景情况:
- 是一种已知致癌物质,
- 暴露与女性生殖器癌症 (卵巢,子宫内膜,子宫) 之间的关联尚未得到充分证实.
研究的目的:
- 通过分析评估职业暴露与女性生殖器癌症风险之间的关联.
主要方法:
- 在PubMed,SCOPUS和EMBASE的系统文献搜索.
- 包括9个队列研究,使用PRISMA,MOOSE和PECOS指南分析数据.
- 评估研究质量和出版偏差.
主要成果:
- 由于死亡率数据 (RR=1. 69),暴露的总体总结风险比 (RR) 为1.22.
- 宫癌 (1. 24),子宫内膜癌 (1. 21),卵巢癌 (1. 28) 的癌症特异性RR没有统计学意义.
- 没有发现显著的异质性或出版偏差.
结论:
- 职业暴露可能与女性生殖器癌症死亡率的增加有关.
- 由于潜在的混因素和研究局限性,目前的证据是不确定的.
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