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在局部性前列腺癌中 PTEN 表达的预后价值

Ayoub Bellouti¹, Nicolas Sirtaine², Thierry Roumeguere¹

¹Department of Urology, Jules Bordet Institute-Erasme Hospital, Brussels University Hospital, Brussels, Belgium.

World journal of urology

|August 25, 2025

概括

在通过MRI向活检诊断的前列腺癌 (PCa) 患者中,PTEN损失表明预后较差. 这种生物标志物可以改善PCa治疗决策和患者咨询.

科学领域:

癌症学
尿道病学
分子病理学

背景情况:

目前前前列腺癌 (PCa) 风险分层缺乏准确性,特别是在中等风险病例中.
PTEN 损失是攻击性 PCa 的新兴生物标志物.
准确的预后对于治疗决策至关重要.

研究的目的:

在PCa患者中评估PTEN状态的预后值.
评估PTEN在急性前列腺切除术 (RP) 后预测结果中的作用.
通过MRI位活检诊断的患者的PTEN状态是否精细化风险分层.

主要方法:

在213名PCa患者的回顾性分析中,通过PTEN测试进行了MRI向活检.
包括手术后PSA无法检测的患者和至少3个月的随访.
使用卡普兰-梅尔,日志等级测试和考克斯回归模型进行生物化学复发 (BCR) 分析.

主要成果:

在17%的患者中观察到PTEN损失,与更高的临床阶段和ISUP级别相关.
患有PTEN损失的患者显著降低了无BCR存活率,特别是在中等风险小组 (p=0. 03).
独立预测的PTEN损失BCR (HR: 8. 5, p=0. 03).

结论:

在通过MRI向活检诊断并接受RP治疗的PCa患者中,PTEN损失与更差的预后有关.
PTEN测试可以增强PCa患者的咨询和治疗指导.
需要进一步的前性研究来验证这些发现.

关键词:

时间预测情况前列腺癌前列腺切除术风险分层

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