处方阿片类药物使用的美国印第安老人的认知和抑郁:来自强心研究的数据
Ché Ross1, Judith I Tsui2, Jason Deen2
1School of Medicine, University of Washington, Seattle, WA, USA. cross8@uw.edu.
Journal of racial and ethnic health disparities
|August 25, 2025
概括
这项研究没有发现处方阿片类药物使用与美国印第安人的认知能力下降之间有直接联系. 然而,阿片类药物使用与抑郁症增加和生活质量下降有关.
科学领域:
- 流行病学
- 老年学
- 神经科学
背景情况:
- 美国印第安人社区面临着严重的健康差异,导致慢性疾病的风险增加以及阿片类药物处方率的增加.
- 抑郁症在部落群体中很普遍,
- 虽然急性阿片类药物对认知的影响已知,但长期影响,特别是美国印第安人的老年人,还未得到充分研究.
研究的目的:
- 调查处方阿片类药物使用与认知功能,抑郁症状和美国印第安人的生活质量之间的联系.
- 确定针对性预防和干预策略的高风险群体.
- 解决该弱势群体长期使用阿片类药物影响的文献短缺问题.
主要方法:
- 利用来自大脑血管疾病及其后果研究 (CDCAI) 的数据,这是强心研究 (SHS) 的辅助队列.
- 包括818名年龄在64-95岁之间的参与者,他们的认知状况由专家小组在两次访问 (2010-2019) 中进行评判.
- 使用线性回归模型评估认知评分,抑郁症 (CES-D) 和生活质量 (SF36),并使用Stata v18进行分析.
主要成果:
- 在818名参与者的队列中,阿片类药物处方率为12% (n=96).
- 在处方阿片类药物使用者和非使用者之间没有发现神经认知测量显著差异.
- 证实了阿片类药物使用与抑郁症状 (SF36分数) 之间存在显著的关联,总效果β系数为-14. 5 (P < 0. 001).
结论:
- 目前的数据并未明确地表明美国印第安人的处方阿片类药物使用与神经认知变化之间存在关联.
- 结果支持已知的阿片类药物使用,生活质量和抑郁症之间的联系.
- 需要进一步研究以了解长期使用阿片类药物对健康差异和高使用阿片类药物的人群的认知效应.
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