身体活动问题:手术前功能评分的预后影响
在PubMed上查看摘要
概括
此摘要是机器生成的。手术前的身体功能得分预测了膀癌患者的存活率. 较高的分数表明总体存活率更高,复发率更低,这表明预康复的作用.
科学领域
- 尿道病学
- 癌症学
- 与健康相关的生活质量 (HRQOL)
背景情况
- 干细胞切除术 (RC) 是膀皮癌 (UC) 的标准治疗方法.
- 确定的RC预后因素包括瘤阶段和淋巴结参与.
- 术前与健康相关的生活质量 (HRQOL) 在预测RC后的生存期方面的预后价值尚未得到充分研究.
研究的目的
- 通过使用 EORTC QLQ-C30 问卷来调查手术前HRQOL功能评分的预后意义.
- 在接受膀UC治疗的患者中,确定HRQOL域与生存结果 (总生存率和无复发生存率) 之间的关联.
主要方法
- 对276名接受了膀癌RC的患者进行了回顾性分析.
- 评估了手术前的HRQOL领域:身体功能 (PF),角色功能 (RF) 和情绪功能 (EF).
- 使用倾向分数匹配和卡普兰-迈尔/ 考克斯回归分析来评估基于PF分数的生存结果 (≥90对<90).
主要成果
- 患有较高的手术前PF分数 (≥90) 的患者显示5年整体存活率显著改善 (80. 4% vs 55. 5%, p=0. 003),并且复发率降低.
- 低的手术前PF得分是整体存活率较低的独立预测指标 (HR:2. 54, p=0. 002).
- 角色功能得分也影响了整体生存,而情绪功能得分没有显著的关联.
结论
- 从EORTC QLQ-C30获得的手术前的身体和角色功能得分为接受激进切除术的患者提供了有价值的预后见解.
- 身体功能的可修改性表明,从预康复计划中获得潜在的好处,以改善患者的结果.
- 将HRQOL评估纳入常规的手术前评估可以提高个性化风险分层并优化患者护理.
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