对生物治疗有反应的状结膜颗粒瘤
Talha Soorma1, Luciane Dreher Irion1, Andrew James Walkden1
1Manchester Royal Eye Hospital, Manchester, UK.
European journal of ophthalmology
|August 25, 2025
概括
这项研究详细介绍了使用阿达利穆马布 (一种抗TNF疗法) 治疗状结膜炎的首次成功治疗. 这种方法为抗治疗的眼皮沙症患者提供了希望.
科学领域:
- 眼科 眼科
- 免疫学
- 关节病学
背景情况:
- 结膜性沙丘病通常会导致无痕的炎症.
- 形结膜炎是一种罕见的,鲜为人知的类型.
- 对于严重的结状瘤有有限的治疗选择.
研究的目的:
- 报告第一例由生体检查确认的结炎病例.
- 在这种情况下评估抗瘤亡因子 (抗TNF) 治疗的疗效.
- 介绍一种新的治疗方法,用于耐火性眼表沙症.
主要方法:
- 一个47岁男性的病例报告,
- 患者出现了复发性脑膜炎和渐进性结膜颗粒瘤,对皮质类固醇和酸无反应.
- 在常规免疫抑制药物失效后,开始使用阿达利穆巴 (一种抗TNF药物).
主要成果:
- 在六个月内,Adalimumab治疗导致了眼部表面炎症的消失.
- 在炎症控制后进行了成功的白内障手术.
- 得到了非死性粒状炎症的组织学确认.
结论:
- 这是第一例与状腺相关的结膜炎对抗TNF治疗有反应的记录.
- 在耐治疗病例中,阿达利穆巴显著有效.
- 这表明阿达利穆马布可能是治疗严重的眼皮表面瘤的一个有价值的选择.
相关概念视频
01:27Tumor Immunotherapy
660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
231
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
231